Principal Biophysicist/Biophysical Scientist

Where curiosity meets purpose-join us in shaping the future of science.

Proclinical is seeking a Principal Biophysicist/Biophysical Scientist to join a dynamic Drug Discovery team based in Cambridge, UK. This role focuses on designing and developing biophysical assays to characterize cancer targets at the molecular level, with the goal of advancing novel cancer treatments. You will play a key role in implementing innovative technologies and collaborating with industry and academic partners to drive therapeutic innovation.

Responsibilities:

• Design and develop physiologically relevant biophysical assays to characterize cancer targets.
• Profile structure-binding and structure-kinetic relationships of small molecules and antibodies.
• Characterize mechanisms of action to inform dose prediction and clinical efficacy.
• Stay updated on cutting-edge biophysical techniques and implement new technologies.
• Lead assay development for a range of target classes.
• Provide scientific leadership and strategic direction within the Drug Discovery team.
• Collaborate with internal teams and external partners to progress projects from idea to pre-clinical candidate.

Key Skills and Requirements:

• Background in biophysics or a related discipline (BSc, MSc, or PhD preferred; relevant experience may substitute for education).
• Expertise in dissecting enzyme and small molecule inhibitor mechanisms using biophysical methods.
• Practical experience with established biophysical techniques such as SPR, ITC, MST, and DSF-TSA.
• Familiarity with emerging technologies like GCI and Spectral Shift.
• Proven track record in assay development across various target classes.
• Strong scientific leadership skills and ability to provide strategic direction.
• Recognized external reputation through publications, conference presentations, or professional networks.

If you are having difficulty in applying or if you have any questions, please contact Ruhee Saleh at r.saleh@proclinical.com.

Apply Now:

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