Senior Scientist (I/II)/Principal Scientist, LNP Formulation job in San Francisco, USA

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

Job type: Permanent

Discipline: Biological Sciences

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is seeking a Senior Scientist I/II or Principal Scientist, LNP Formulation to lead lipid nanoparticle (LNP) formulation discovery and scale up activities for non-viral delivery technologies at a leading gene editing biotech. The candidate will be responsible for the screening of various lipids and formulation/process parameters for lead optimisation for delivery. In addition, you will be responsible for in-house research-scale production, related process development, and quality control of the test articles to support ex-vivo and in-vivo studies.

Reponsibilities

Lead DOE-based LNP formulation screening/discovery campaigns directed toward in vivo and ex vivo delivery of proprietary CRISPR-based gene editing systems.
Design, implement and execute early process development activities for LNP scale-up.
Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings.
Explore and evaluate non-viral delivery technologies for various therapeutics indications.
Explore new orthogonal characterisation assays and rigorously QC all the test articles.
Manage the non-viral delivery projects to support deliverables along established timelines.
Train, guide, and manage the researchers on various non-viral delivery activities.

Requirements:

Bachelor's degree in related field and 8+ years industry experience (or Master's degree and 6+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 2+ years of industry experience).
Expertise in LNP formulation screening and optimisation .
Expertise in using design of experiment (DOE), relevant statistical softwares (JMP), and predictive analytics for formulation discovery.
Exposure to LNP scale-up and process development activities.
Hands-on expertise in various basic analytical and biophysical methods/assays of LNP characterisation such as, particularly size, zeta potential, and nucleic acid encapsulation/release, PKa, etc.
Foundation in experimental documentation, basic statistical analysis and data presentation .
Experience working with internal and external research collaborators and CROs.
Highly motivated, hard working, and collaborative spirit.

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at (+1) 646-868-5142.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

#LI-DB3

#Scientific

Related jobs

Microbiology Technologist

Salary

Highly Competitive

Location:

Barnard Castle, England

Proclinical is seeking a dedicated Microbiology Technologist to join our client's team team in Barnard Castle.

Rezaune Koopman

Apply

Executive Director, Cell Therapy Quality Control

Salary

US$250000.00 - US$280000.00 per annum + Highly Competitive Salary

Location:

Philadelphia, USA

Proclinical is seeking an Executive Director for Quality Control Operations in the gene therapy and pharmaceuticals sector.

Shannon Briggs

Apply

Quality Control Analyst II: Microbiology

Salary

Highly Competitive

Location:

Philadelphia, USA

Proclinical is seeking a Quality Control Analyst II specializing in Microbiology to join our client's team in Philadelphia.

Shannon Briggs

Apply

Senior / Principal Scientist

Salary

Highly Competitive

Location:

Boston, USA

Proclinical is working with a biotechnology company to recruit for a Senior/Principal Scientist, Antibody-Oligonucleotide Bioconjugation. This permanent position is based in Boston, Massachusetts.