Scientist: Medicinal Chemistry - Contract - San Francisco, CA
Are you ready to turn precision into progress and play a key role in shaping the future of pharmaceutical innovation?
Proclinical is seeking a talented and passionate Medicinal Chemist to join our small-molecule drug discovery team.
Primary Responsibilities:
In this role, you will contribute to advancing science and developing life-changing medicines. You will contribute to all stages of drug discovery, from hit identification to lead optimization, within a collaborative and fast-paced environment.
Skills & Requirements:
- Education and Experience:D. in Organic Chemistry alongside 6+ years experience, or equivalent experience in chemical research, preferably within a biotechnology or pharmaceutical setting.
- Expertise in Synthetic/Medicinal Chemistry: Proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of at least one first-authored publication(s) and an understanding of medicinal chemistry principles.
- Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization.
- Structure-Based Drug Design: Experience with structure-based drug design is highly preferred.
The Scientist's responsibilities will be:
- Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection.
- Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology.
- Design and Synthesize Novel Compounds: Apply innovative structure- and computationally-driven, as well as property-based design principles, to design and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners.
- Analyze and Interpret Data: Utilize strong analytical thinking skills to organize and analyze structure-activity relationship (SAR) data sets to drive design ideas and impact program direction.
- Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity).
- Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry department support.
- Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders
Compensation:
If you are having difficulty in applying or if you have any questions, please contact Shannon Briggs at s.briggs@proclinical.com
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.
By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy
.png)
