Scientist: Medicinal Chemistry - Contract - San Francisco, CA
Are you ready to turn precision into progress and play a key role in shaping the future of pharmaceutical innovation?
Proclinical is seeking a talented and passionate Medicinal Chemist to join our small-molecule drug discovery team.
Primary Responsibilities:
In this role, you will contribute to advancing science and developing life-changing medicines. You will contribute to all stages of drug discovery, from hit identification to lead optimization, within a collaborative and fast-paced environment.
Skills & Requirements:
- Education and Experience:D. in Organic Chemistry alongside 6+ years experience, or equivalent experience in chemical research, preferably within a biotechnology or pharmaceutical setting.
- Expertise in Synthetic/Medicinal Chemistry: Proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of at least one first-authored publication(s) and an understanding of medicinal chemistry principles.
- Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization.
- Structure-Based Drug Design: Experience with structure-based drug design is highly preferred.
The Scientist's responsibilities will be:
- Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection.
- Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology.
- Design and Synthesize Novel Compounds: Apply innovative structure- and computationally-driven, as well as property-based design principles, to design and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners.
- Analyze and Interpret Data: Utilize strong analytical thinking skills to organize and analyze structure-activity relationship (SAR) data sets to drive design ideas and impact program direction.
- Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity).
- Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry department support.
- Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders
Compensation:
If you are having difficulty in applying or if you have any questions, please contact Shannon Briggs at s.briggs@proclinical.com
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
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