Principal Scientist, in-vivo Pharmacology/Immuno-Oncology job in Lexington, USA

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Last Name*

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First Name*

Last Name*

Email*

Phone Number*

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Are you an employer or a jobseeker?*

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First Name*

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Job type: Permanent

Discipline: Biological Sciences, Immunology, Molecular Biology

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is seeking a talented principal scientist with strong in vivo pharmacology and tumor immunology experience to support the preclinical research and discovery efforts for our expanding portfolio of company-based therapeutics. The successful candidate will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working across programs in a small company environment. This position will report to the Director of In vivo Pharmacology.

Job Responsibilities:

Provide in vivo pharmacology expertise and strategic guidance as a core team member for one or more company programs including both internal programs and our collaborative partnership with Genentech
Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stake holders to drive decisions
Manage in vivo pharmacology research through a network of CROs and academic collaborations
Effectively document and communicate results company-wide in diverse settings ranging from project team to leadership team meetings
Provide in vitro pharmacology expertise and CRO management when needed
Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development
Lead in vivo pharmacology sample management and downstream analysis efforts

Skills and Requirements

PhD degree in the biological sciences with 8+ years of additional relevant experience (industry experience required), or a MS degree with 12+ years of additional industry experience
Experience using multiple types of in vivo oncology models including IO models is required
Experience in generation, characterization and use of immunocompetent humanized mouse models of cancer is preferred
Familiarity with the immunophenotyping of excised mouse tumors using high-dimensional methodologies including flow / mass cytometry is favorable
Experience in in vivo model development and validation
Experience in managing external work/collaborations is essential
An established background in tumor immunology is required
A strong background in cancer biology is preferred
Capability of working both independently and as part of multiple collaborative teams
Previous experience leading well-defined activities or specific function to achieve a project or corporate goal
Attention to detail and strong interpersonal, organizational and communication skills
Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or s.amark@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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