Principal Scientist, in-vivo Pharmacology/Immuno-Oncology

Proclinical is seeking a talented principal scientist with strong in vivo pharmacology and tumor immunology experience to support the preclinical research and discovery efforts for our expanding portfolio of company-based therapeutics. The successful candidate will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working across programs in a small company environment. This position will report to the Director of In vivo Pharmacology.

Job Responsibilities:

• Provide in vivo pharmacology expertise and strategic guidance as a core team member for one or more company programs including both internal programs and our collaborative partnership with Genentech
• Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stake holders to drive decisions
• Manage in vivo pharmacology research through a network of CROs and academic collaborations
• Effectively document and communicate results company-wide in diverse settings ranging from project team to leadership team meetings
• Provide in vitro pharmacology expertise and CRO management when needed
• Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development
• Lead in vivo pharmacology sample management and downstream analysis efforts

Skills and Requirements

• PhD degree in the biological sciences with 8+ years of additional relevant experience (industry experience required), or a MS degree with 12+ years of additional industry experience
• Experience using multiple types of in vivo oncology models including IO models is required
• Experience in generation, characterization and use of immunocompetent humanized mouse models of cancer is preferred
• Familiarity with the immunophenotyping of excised mouse tumors using high-dimensional methodologies including flow / mass cytometry is favorable
• Experience in in vivo model development and validation
• Experience in managing external work/collaborations is essential
• An established background in tumor immunology is required
• A strong background in cancer biology is preferred
• Capability of working both independently and as part of multiple collaborative teams
• Previous experience leading well-defined activities or specific function to achieve a project or corporate goal
• Attention to detail and strong interpersonal, organizational and communication skills
• Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or s.amark@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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