Principal Scientist, in-vivo Pharmacology/Immuno-Oncology

Highly Competitive Salary
  1. Permanent
  2. Biological Sciences, Immunology, Molecular Biology
  3. United States
Lexington, USA
Posting date: 13 May 2021

Proclinical is seeking a talented principal scientist with strong in vivo pharmacology and tumor immunology experience to support the preclinical research and discovery efforts for our expanding portfolio of company-based therapeutics. The successful candidate will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working across programs in a small company environment. This position will report to the Director of In vivo Pharmacology.

Job Responsibilities:

  • Provide in vivo pharmacology expertise and strategic guidance as a core team member for one or more company programs including both internal programs and our collaborative partnership with Genentech
  • Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stake holders to drive decisions
  • Manage in vivo pharmacology research through a network of CROs and academic collaborations
  • Effectively document and communicate results company-wide in diverse settings ranging from project team to leadership team meetings
  • Provide in vitro pharmacology expertise and CRO management when needed
  • Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development
  • Lead in vivo pharmacology sample management and downstream analysis efforts

Skills and Requirements

  • PhD degree in the biological sciences with 8+ years of additional relevant experience (industry experience required), or a MS degree with 12+ years of additional industry experience
  • Experience using multiple types of in vivo oncology models including IO models is required
  • Experience in generation, characterization and use of immunocompetent humanized mouse models of cancer is preferred
  • Familiarity with the immunophenotyping of excised mouse tumors using high-dimensional methodologies including flow / mass cytometry is favorable
  • Experience in in vivo model development and validation
  • Experience in managing external work/collaborations is essential
  • An established background in tumor immunology is required
  • A strong background in cancer biology is preferred
  • Capability of working both independently and as part of multiple collaborative teams
  • Previous experience leading well-defined activities or specific function to achieve a project or corporate goal
  • Attention to detail and strong interpersonal, organizational and communication skills
  • Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.