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Last Name*

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First Name*

Last Name*

Email*

Phone Number*

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Are you an employer or a jobseeker?*

Message

First Name*

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Phone Number*

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Are you an employer or a jobseeker?*

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Job type: Permanent

Discipline: Pharmacology

Location: United Kingdom

Proclinical has partnered with a global pharmaceutical company in search for the Vice President of Translational Development. The UK based role will ask you to provide translational, scientific and immuno-oncology development strategic expertise, to all aspects of the business.

Job Responsibilities

Has current, state-of-the-art knowledge of oncology immunotherapy, mechanisms of action, biomarkers, bioinformatics and toxicity, and new IO therapies in development.
Leads the development of biomarker strategies and translational hypotheses for all projects including target proximal pharmacodynamics, distal mechanism of actions and patient selection/stratification.
Creates pharmacokinetic/pharmacodynamic models that predict the clinical dose response and can be refined using clinical data to create recommended Phase II dosing regimen.
Forwards and back translates mechanism of action and biomarker data (preclinical and clinical) in conjunction with partners e.g. translational medicine and preclinical biology to test translational hypotheses.
Develops data science, analysis and visualisation systems and processes to enable rapid translational insights to inform development decisions.
Implements the necessary assays as "fit-for-purpose" to address the translational hypotheses and in line with regulatory requirements from a quality perspective.
Reduces plans to practice by effective project management to ensure they are integrated within the overall development programme with programme managers and business support functions e.g. finance, legal, BD
Creates clear reporting of outcomes of studies to project teams and project review boards.
Critically reviews technical reports and lead medical writing for accountable areas in regulatory submissions e.g IND modules 2 and 4, IB

Skills and Requirements

Entrepreneurial, self-driven mindset with the ability to bring creative solutions to challenges.
Flexible and innovative, and able to deal effectively with ambiguity.
Strong personal values and the highest level of integrity and ethics.
Possesses maturity and good judgment; swift action taker; decisive and makes informed decisions.
Hands-on, pragmatic, highly committed and leads by example.
Strong listening, communication and interpersonal skills.
Possesses vision, global awareness and sensitivity, and works effectively across cultures.

To Apply

ProClinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

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