Lead the science that shapes every dose, every study, and the future of an entire portfolio.
Proclinical is seeking an exceptional Clinical Pharmacology leader to define, drive, and own clinical pharmacology strategy across a diverse and exciting portfolio. This is a senior, hands-on leadership role with significant influence across early and late-stage development.
The successful candidate will ensure the consistent application of best-in-class clinical pharmacology methodology, informing dose selection, study design, and pharmacology-driven decision-making from first-in-human through late-stage clinical development.
This role offers a unique opportunity to shape portfolio strategy at senior level while remaining deeply engaged in scientific delivery.
Please note that to be considered for this role you must have the right to work in this location or hold an EU passport.
Responsibilities:
Clinical Pharmacology Leadership
- Lead and own clinical pharmacology strategy across the portfolio, ensuring rigorous application of PK, PD, exposure-response, and dose-selection principles.
- Deliver program-specific clinical pharmacology strategies and outputs through a blend of direct, hands-on contribution and management of an external consultant network.
- Serve as the senior clinical pharmacology authority, contributing to governance forums and portfolio investment decisions.
- Partner with Discovery DMPK to ensure a seamless transition from discovery to clinical development, aligning pharmacology approaches across stages.
Translational Biology Partnership
- In collaboration with program biologists and scientific leads, develop quantitative translational biology plans that demonstrate drug exposure, target engagement, and early evidence of efficacy.
- Advise on methodologies and endpoints to support high-quality early clinical studies.
Study Design, Execution & Interpretation
- Provide expert input into the design and interpretation of Phase 1 studies, including dose selection, dose-escalation strategies, and integration of exposure-response/safety relationships.
- Translate complex PK/PD and pharmacology data into clear, actionable recommendations.
Modelling & Quantitative Approaches
- Apply PK and PK/PD modelling approaches to inform clinical decision-making.
- Collaborate with internal or external modelling specialists where needed.
Regulatory & Cross-Functional Contributions
- Contribute to and review clinical pharmacology sections of regulatory submissions.
- Support regulatory interactions as the organisation's senior clinical pharmacology subject-matter expert.
Key Skills and Requirements:
- 10+ years of experience in clinical pharmacology within biotech or pharma.
- Demonstrated track record of hands-on delivery and scientific excellence in clinical pharmacology across both small molecules and biologics.
- Proven ability to use non-clinical PK/PD and translational data to shape clinical strategy.
- Ideally, experience generating or analysing complex biomarker datasets to characterise drug pharmacology.
- Experience influencing senior scientific, clinical, and regulatory stakeholders.
Skills & Competencies
- Strategic leader with experience owning clinical pharmacology at a portfolio level.
- Strong interpersonal, communication, and matrix leadership capabilities.
- Ability to operate effectively in complex, cross-functional environments.
Qualifications
- PhD, PharmD, MD, or equivalent in clinical pharmacology, pharmaceutical sciences, or a related discipline.
If you are having difficulty in applying or if you have any questions, please contact Neil Walton at neil.watson@proclinical.com.
Apply Now:
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.
By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy
Proclinical is seeking an exceptional Clinical Pharmacology leader to define, drive, and own clinical pharmacology strategy across a diverse and exciting portfolio. This is a senior, hands-on leadership role with significant influence across early and late-stage development.
The successful candidate will ensure the consistent application of best-in-class clinical pharmacology methodology, informing dose selection, study design, and pharmacology-driven decision-making from first-in-human through late-stage clinical development.
This role offers a unique opportunity to shape portfolio strategy at senior level while remaining deeply engaged in scientific delivery.
Please note that to be considered for this role you must have the right to work in this location or hold an EU passport.
Responsibilities:
Clinical Pharmacology Leadership
- Lead and own clinical pharmacology strategy across the portfolio, ensuring rigorous application of PK, PD, exposure-response, and dose-selection principles.
- Deliver program-specific clinical pharmacology strategies and outputs through a blend of direct, hands-on contribution and management of an external consultant network.
- Serve as the senior clinical pharmacology authority, contributing to governance forums and portfolio investment decisions.
- Partner with Discovery DMPK to ensure a seamless transition from discovery to clinical development, aligning pharmacology approaches across stages.
Translational Biology Partnership
- In collaboration with program biologists and scientific leads, develop quantitative translational biology plans that demonstrate drug exposure, target engagement, and early evidence of efficacy.
- Advise on methodologies and endpoints to support high-quality early clinical studies.
Study Design, Execution & Interpretation
- Provide expert input into the design and interpretation of Phase 1 studies, including dose selection, dose-escalation strategies, and integration of exposure-response/safety relationships.
- Translate complex PK/PD and pharmacology data into clear, actionable recommendations.
Modelling & Quantitative Approaches
- Apply PK and PK/PD modelling approaches to inform clinical decision-making.
- Collaborate with internal or external modelling specialists where needed.
Regulatory & Cross-Functional Contributions
- Contribute to and review clinical pharmacology sections of regulatory submissions.
- Support regulatory interactions as the organisation's senior clinical pharmacology subject-matter expert.
Key Skills and Requirements:
- 10+ years of experience in clinical pharmacology within biotech or pharma.
- Demonstrated track record of hands-on delivery and scientific excellence in clinical pharmacology across both small molecules and biologics.
- Proven ability to use non-clinical PK/PD and translational data to shape clinical strategy.
- Ideally, experience generating or analysing complex biomarker datasets to characterise drug pharmacology.
- Experience influencing senior scientific, clinical, and regulatory stakeholders.
Skills & Competencies
- Strategic leader with experience owning clinical pharmacology at a portfolio level.
- Strong interpersonal, communication, and matrix leadership capabilities.
- Ability to operate effectively in complex, cross-functional environments.
Qualifications
- PhD, PharmD, MD, or equivalent in clinical pharmacology, pharmaceutical sciences, or a related discipline.
If you are having difficulty in applying or if you have any questions, please contact Neil Walton at neil.watson@proclinical.com.
Apply Now:
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.
By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy
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