(Senior) Scientist, Oligonucleotide Biology

Proclinical is currently recruiting for a (Senior) Scientist in Oligonucleotide Chemistry to join a newly founded Biotech in Boston, MA seeking to make the world's first programmable RNA medicines and deliver innovative oligonucleotide therapeutics to patients.

As a Scientist in the biotech's biology group, you will be a key contributor to a diverse team working on novel siRNA modalities as well as in vitro assays and in vivo measurements of drug activity. The ideal candidate will have experience with siRNA/Oligotherapeutics, molecular biology, cell biology and in vivo assays. In this role you will work closely with colleagues to develop new drug designs developed by the biotech as well as to validate compounds. You will be supporting the development of the next generation of RNA drugs and ensuring that the current generation reach the patients that need them. We are seeking innovators, thinkers and doers.

Job Responsibilities:

• Be one of the first members of the biology team, helping to shape its culture and dynamic
• Perform experiments within the team: Execution and understanding of protocols for protein chemistry and target validation, such as SDS-PAGE, ELISA, western blots
• Proven expertise in RNAi space
• Clearly document experimental workflows and results; Communicate findings to the team and management when required
• In vivo experience
• Oversee day to day lab tasks; Enjoy benchwork
• Development, optimization, and troubleshooting of methods to screen and characterize activity of siRNA/RNA/antisense oligonucleotides (ASOs)
• Research and development of in vitro assays to evaluate impact of siRNA/antisense oligonucleotides on RNA transcripts, protein expression, and other project-specific assays
• Apply molecular and cell-based assays including but not limited to RNA transfection, RNA & protein isolation, gene expression analysis (RT-qPCR & RNASeq), western blot, and fluorescence immunocytochemistry

Skills and Requirements:

• PhD degree: relevant life sciences discipline preferred
• 1-3 for Scientist, >3 for Senior Scientist
• Familiarity with siRNA, ASOs and gene silencing
• Ability to adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.

If you are having difficulty in applying or if you have any questions, please contact Marta Suazo at 347-960-4479 or m.suazo@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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