Senior Scientist Oligonucleotide Biology

Highly Competitive Salary
  1. Permanent
  2. Senior/Director & VP, Biochemistry, Biological Sciences
  3. United States
Boston, USA
Posting date: 13 Oct 2020
SC.SA.33491

Proclinical is currently recruiting for an Investigator/Senior Investigator of Oligonucleotide Biology with a leading life science group located in Boston, MA. As the Investigator/Senior Investigator, you will be a part of a group that invents, discovers, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions for Oncology, CNS, metabolism and other areas of high unmet medical need.

Job Responsibilities:

  • Develop and maintain cell culture assays for screening antisense/siRNA-based and innate immune receptor-targeted DNA/RNA oligonucleotides for various disease indications.
  • Carry out and establish molecular basis of mechanisms of diseases and develops biomarkers
  • Develop and supervise/manage biology laboratory and mentor junior colleagues.
  • Design and conduct in vivo disease model studies at CROs and interpret data.
  • Collaboratively work with chemistry, formulation and bioinformatics scientists.
  • Contribute to high impact research publications/patent applications and regulatory filings

Skills and Requirements:

  • PhD in Biology/Biochemistry or a relevant subject area from a reputed University with 6+ years of relevant postdoctoral/industrial experience within the area of in vitro and in vivo antisense/siRNA biology.
  • Thorough knowledge of working with DNA and RNA oligonucleotides, antisense and/or siRNA screening.
  • Pertinent experience of handling, growing and maintaining cell lines and developing cell culture assays.
  • Experience in gene expression analysis using RT-PCR and other related techniques, and protein expression analysis by ELISA, FACS, Western blots.
  • Experience working with primary cells from animals and humans.
  • Hands on experience running in vivo studies and directly dealing with CROs. Experience in designing and writing in vivo study protocols, engaging CROs, data analysis, including statistical analysis, and interpretation.
  • Experience working with innate immune receptor modulators in vitro and in vivo is advantageous.
  • Thorough knowledge and demonstrated experience of using cutting edge molecular biological and immunological experimental techniques.
  • Experience working as a team member on projects and willing to collaborate with internal project teams developing various nucleic acid therapeutics.
  • Effective presentation skills of methodologies and results internally to colleagues, including bench scientists, project team leaders, research management, and at scientific conferences.
  • Ability to independently translate strategy into action in a timely manner.
  • Demonstrated experience successfully prioritizing and managing projects and timelines.
  • Strong problem-solving and troubleshooting skills.
  • Strong verbal and written communication skills and team work ethics.


If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or s.amark@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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