Senior Scientist Oligonucleotide Biology job in Boston, USA

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Last Name*

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First Name*

Last Name*

Email*

Phone Number*

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Are you an employer or a jobseeker?*

Message

First Name*

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Are you an employer or a jobseeker?*

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Job type: Permanent

Discipline: Senior/Director & VP, Biochemistry, Biological Sciences

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is currently recruiting for an Investigator/Senior Investigator of Oligonucleotide Biology with a leading life science group located in Boston, MA. As the Investigator/Senior Investigator, you will be a part of a group that invents, discovers, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions for Oncology, CNS, metabolism and other areas of high unmet medical need.

Job Responsibilities:

Develop and maintain cell culture assays for screening antisense/siRNA-based and innate immune receptor-targeted DNA/RNA oligonucleotides for various disease indications.
Carry out and establish molecular basis of mechanisms of diseases and develops biomarkers
Develop and supervise/manage biology laboratory and mentor junior colleagues.
Design and conduct in vivo disease model studies at CROs and interpret data.
Collaboratively work with chemistry, formulation and bioinformatics scientists.
Contribute to high impact research publications/patent applications and regulatory filings

Skills and Requirements:

PhD in Biology/Biochemistry or a relevant subject area from a reputed University with 6+ years of relevant postdoctoral/industrial experience within the area of in vitro and in vivo antisense/siRNA biology.
Thorough knowledge of working with DNA and RNA oligonucleotides, antisense and/or siRNA screening.
Pertinent experience of handling, growing and maintaining cell lines and developing cell culture assays.
Experience in gene expression analysis using RT-PCR and other related techniques, and protein expression analysis by ELISA, FACS, Western blots.
Experience working with primary cells from animals and humans.
Hands on experience running in vivo studies and directly dealing with CROs. Experience in designing and writing in vivo study protocols, engaging CROs, data analysis, including statistical analysis, and interpretation.
Experience working with innate immune receptor modulators in vitro and in vivo is advantageous.
Thorough knowledge and demonstrated experience of using cutting edge molecular biological and immunological experimental techniques.
Experience working as a team member on projects and willing to collaborate with internal project teams developing various nucleic acid therapeutics.
Effective presentation skills of methodologies and results internally to colleagues, including bench scientists, project team leaders, research management, and at scientific conferences.
Ability to independently translate strategy into action in a timely manner.
Demonstrated experience successfully prioritizing and managing projects and timelines.
Strong problem-solving and troubleshooting skills.
Strong verbal and written communication skills and team work ethics.

If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or s.amark@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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Salary

US$120 - US$130 per hour

Location:

Cambridge, USA

Ready to bridge the gap between breakthrough science and real-world therapies? Join our client in turning discovering into impact with the pharmaceutical industry!