Senior Scientist, Mass Spectrometry - Contract - Tarrytown, NY
Are you looking to make an impact with your innovation? We are working with a well-established pharmaceutical company to recruit for a dedicated Senior Scientist.
Proclinical is seeking a highly motivated Scientist in support our client's R&D programs. Our client focuses on using Mass Spectrometry for the biochemical characterization of emerging novel therapeutic modalities as well as therapeutic monoclonal antibodies at all stages of development.
Primary Responsibilities:
This role will develop LC-MS methods and/or other analytical strategies for elucidating and characterizing novel therapeutics (such as AAVs) and antibody attributes such as primary structures, disulfide linkages, PTMs, product and process related impurities, charge/size variants, sequence variants, etc. You will conduct analytical method qualification and develop innovative technologies to support a diverse R&D pipeline.
A Typical Day In This Role Looks Like:
- Develop primarily LC-MS based analytical methods to support various R&D programs.
- Perform LC-MS data analysis using various software and bioinformatic tools to elucidate the quality attributes of therapeutic proteins and other novel modalities.
- Support R&D activities and regulatory applications and deepen our knowledge of antibody therapeutics and other emerging novel modalities.
- Perform sample preparation and LC-MS-based experiments independently based on SOPs and document experiments, results and findings in electronic laboratory notebook (ELN) entries; present data at group and project meetings; write technical reports, SOPs, and regulatory filing reports, etc.
- Summarize results in a concise format (graphs, figures, tables, etc.) to support presentations, peer-reviewed publications, and regulatory documents, etc.
This Role May Be For You If:
- You have knowledge and hands-on experience in LC-MS based sample preparation for proteins and peptides are required. Experience in specialized LC-MS based techniques such as hydrogen-deuterium exchange mass spectrometry (HDX-MS) and quantitative proteomics is a plus. Knowledge and experience in AAV virology and structural biology is a plus. Knowledge in enzyme function and kinetics is a plus.
- Strong verbal and written communication skills as well as good interpersonal skills are essential. The ability to learn new technologies and solve problems is essential. A passion for science and the motivation to contribute within a team environment are necessary.
- This role is for you if you are motivated, results-driven, efficient, and able to perform key responsibilities in an innovative, fast-paced, team environment.
To be considered for this role, you must have a master's degree (or higher) in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field along with 5+ years of industrial or academic experience for a master's degree or 0-3 years for a PhD degree.
Compensation:
If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at m.raletz@proclinical.com
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
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