Senior Research Associate/Scientist, High Throughput Screening

Proclinical is seeking an exceptional Research Associate to join a growing team. As a Senior Research Associate/Associate Scientist, you will work to support key development programs and senior team members by conducting in-vitro studies to support our RNA-modality platform screening efforts. You will be generating and maintaining mammalian cell lines as well as conducting various assays (cell-based, molecular, biochemical, and immune) based on established protocols.

Job Responsibilities:

• Participate in high throughput cell-based assay development; and perform cellular/molecular biology techniques including the generation of stable reporter cells for fluorescence, qPCR, and luciferase related assays.
• Follow and execute standardized protocols for high to medium throughput assays, with high attention to detail and effectively communicating results
• Utilize lab automation equipment and high-throughput instrumentation to conduct assays and experiments
• Assist colleagues in experiments to optimize precision, accuracy, reproducibility, and throughput for core platform assays
• Execute and optimize processes within the lab to increase efficiency and effectiveness, including managing biologics inventory, lab consumables, chemicals, and equipment.
• Work closely with engineering/scientific colleagues to perform HTS/HCS campaigns, and to streamline data analysis workflow. Analyze experimental data and present results at project/team meetings.
• Convert traditional low-throughput biochemical and cell-based assays into HTS amenable formats. (Experimental Design, Assay Optimization, Method Validation, and Root Cause Analysis).

Skills and Responsibilities:

• BS, MS or PhD degree in relevant fields
• Experience working in a Biotech/Pharmaceutical/Research laboratory environment
• Experience with tissue culture and aseptic techniques for Cellular and Molecular Biology
• Excellent organizational, verbal, written communication and interpersonal skills and willingness to work within a collaborative team setting and across functional areas
• Experience with electronic laboratory notebook (ELN), SOP development, and reagent management.
• Experience with cell and molecular biology analytical techniques, such as spectrophotometry (Nanodrop), qPCR, Western blot, In Situ Hybridization, immunofluorescence imaging, and microscopy.
• Excellent communication, organization, and problem-solving skills.
• Motivation to learn new scientific techniques and to work in a team environment is necessary.

Desired Skills:

• Advanced degree (MS/PhD) in a scientifically related field or equivalent work experience
• Direct technical experience in Biotech/Pharma Research and Development
• Experience with primary human derived cell culture
• Experience with medium/high throughput small molecule or Oligonucleotide screening using bioluminescent assay or high content imaging
• Strong expertise on assay design, automation, optimization, validation, and implementation of routine cell-based assay to support drug discovery programs
• Extensive experience in mammalian cell culture, cell line development, characterization, and optimization. Proficient in DNA/RNA delivery by transfection, transduction, and electroporation

Incentives:

• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
• A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
• Participation in an unprecedented opportunity to advance a single RNA-modality medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
• Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at (+1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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