Senior Director, Antibody Bioconjugate Discovery

Highly Competitive Salary
  1. Permanent
  2. Analytical Chemistry, Biochemistry, Biological Sciences
  3. United States
Boston, USA
Posting date: 24 Apr 2024

Senior Director, Antibody Bioconjugate Discovery - Boston, MA - Permanent

Proclinical Staffing is seeking a Senior Director, of Antibody Bioconjugate Discovery to join an innovative biotech developing next generation neurogenetic medicines. This is a permanent role located in Boston, MA.

Primary Responsibilities:

In this role, you will oversee all aspects of antibody and antibody bioconjugate technology development and drug discovery to develop next generation CNS therapeutics.

Skills & Requirements:

  • PhD in chemistry, biochemistry, chemical biology, or a related field with 10+ years of industry experience
  • Demonstrated leadership and management experience with a track record of leading teams and projects to successful endpoints
  • Deep expertise in antibody/nanobody generation utilizing a wide range of technologies such as hybridoma, phage display, single B-cell screening, etc.
  • Demonstrated experience developing antibody bioconjugates, bispecific and multi-specific antibody formats for receptor-drive tissue targeting
  • Familiarity with performing develop ability/manufacturability assessments for selection and optimization of antibodies and antibody formats
  • Experience using bioinformatics tools for sequence and structure analysis
  • Proven leadership skills with mentoring and leading teams in therapeutic antibody development
  • Ability to work collaboratively in a high-paced project team environment, meet deadlines, and prioritize work across multiple projects
  • Strong written and verbal communication skills
  • Experience in CNS delivery strongly preferred

The Senior Director will:

  • Lead efforts in antibody/nanobody development and engineering, including bispecific, single domain, and multi-domain antibodies for non-viral CNS-penetrant therapeutic programs
  • Utilize multiple strategies for antibody discovery such as hybridoma screening, B-cell screening, phage display to select and optimize top antibody candidates for affinity, transcytosis and other properties
  • Design and execute protein engineering strategies to deliver developable biologics formats by applying molecular biology, structure-guided, computational, combinatorial/display approaches
  • Lead and mentor an antibody engineering and molecular biology team of scientists responsible for designing, generating, and characterizing antibody-based therapeutics
  • Lead technology development in antibody engineering and contribute to broadening Voyager's intellectual property portfolio
  • Hire, manage and develop a team of scientists/research associates fostering an environment of creativity, a strong work ethic and teamwork
  • Develop and manage operating budget

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 857-362-9542 or

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.