Scientist/ Senior Scientist, Oligonucleotide Chemistry

Highly Competitive Salary
  1. Permanent
  2. Medicinal Chemistry
  3. United States
Cambridge, USA
Posting date: 09 Aug 2023

This vacancy has now expired. Please see similar roles below...

We are seeking a (Senior) Scientist in Synthetic & Medicinal Chemistry to join a newly founded Biotech in Cambridge, MA seeking to make the world's first programmable RNA medicines and deliver innovative oligonucleotide therapeutics to patients. If you are excited to join a innovative, dynamic and visionary team creating programmable medicines, this could be an exciting role for you.

With a rich product pipeline covering multiple therapeutic areas in various stage of development, strong financial backing, an experienced management team and world class Scientific Advisory Board, this is an exciting opportunity to work with leaders in the field.

As a (Senior) Scientist in the Chemistry group, you will be a key contributor to a diverse team working on novel siRNA. The ideal candidate will have a strong background in synthetic organic chemistry as well as an interest in siRNA/Oligotherapeutics. In this role you will work closely with colleagues to develop new drugs designs developed by Sirius as well as to synthesise compounds.


  • Responsible for the synthesis, purification and characterisation of organic compounds/oligonucleotides.
  • Support ordering and general upkeep of RNA synthesisers and other related equipment.
  • Perform synthesis projects independently or as part of a team.
  • Act to mentor junior staff as the company grows.
  • Confident in analytical methods and analytical instrumentation [HPLC LC-MS MS NMR etc.].
  • Clearly document experimental workflows and results.
  • Communicate findings to the team and management when required.
  • Oversee day to day lab tasks.
  • Enjoy benchwork.


  • PhD degree: relevant Synthetic organic chemistry discipline preferred.
    • 1-3 years' experience for Scientist.
    • >3 for Senior Scientist.
  • Familiarity with siRNA, ASOs and gene silencing is a plus.
  • Ability to adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 857-362-9542 or

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.