Research specialist, Cell Based Assays

Research Specialist, Cell Based Assays - Contract - Cambridge, Massachusetts

Proclinical is seeking a dedicated and innovative Research Specialist on a temporary contract based in Cambridge, Massachusetts.

Primary Responsibilities:

This role offers the chance to contribute to a growing portfolio of targeted therapies in a dynamic and fast-paced research environment. The ideal candidate will have experience in exploring cellular and molecular mechanisms, particularly in relation to kinase target pathway modulation, off-target liabilities, and resistance.

Skills & Requirements:

• MS/BS in oncology, cellular biology, molecular biology, or related discipline.
• Experience in developing and optimizing cell-based assays in multiple platforms (e.g., CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring).
• Familiarity with different molecular and cellular biology techniques (such as Western Blot).
• Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.
• Familiarity with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.
• Experience with standard software analytical tools, xlsx, Prism, or other synergy software.
• Strong oral and written communication skills, as well as excellent documentation and organizational skills.
• A team player, who listens effectively, invites response and discussion.
• Commitment to Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism.

The Research Specialist's responsibilities will be:

• Independently develop, optimize, and troubleshoot cellular screening assays.
• Generate, process, interpret, and present data in cross-functional team meetings.
• Utilize cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.
• Independently design, execute and document experiments to evaluate target dependency, off-target liabilities, phenotypic responses and identifying resistance mechanisms.
• Regularly share and present data with team members.

If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at (+1) 267 428 7770 or m.raletz@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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