Research Specialist, Cell Based Assays - Contract - Cambridge, Massachusetts
Proclinical is seeking a dedicated and innovative Research Specialist on a temporary contract based in Cambridge, Massachusetts.
Primary Responsibilities:
This role offers the chance to contribute to a growing portfolio of targeted therapies in a dynamic and fast-paced research environment. The ideal candidate will have experience in exploring cellular and molecular mechanisms, particularly in relation to kinase target pathway modulation, off-target liabilities, and resistance.
Skills & Requirements:
- MS/BS in oncology, cellular biology, molecular biology, or related discipline.
- Experience in developing and optimizing cell-based assays in multiple platforms (e.g., CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring).
- Familiarity with different molecular and cellular biology techniques (such as Western Blot).
- Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.
- Familiarity with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.
- Experience with standard software analytical tools, xlsx, Prism, or other synergy software.
- Strong oral and written communication skills, as well as excellent documentation and organizational skills.
- A team player, who listens effectively, invites response and discussion.
- Commitment to Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism.
The Research Specialist's responsibilities will be:
- Independently develop, optimize, and troubleshoot cellular screening assays.
- Generate, process, interpret, and present data in cross-functional team meetings.
- Utilize cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.
- Independently design, execute and document experiments to evaluate target dependency, off-target liabilities, phenotypic responses and identifying resistance mechanisms.
- Regularly share and present data with team members.
If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at (+1) 267 428 7770 or m.raletz@proclinical.com.
Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.
Proclinical Staffing is an equal opportunity employer.
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