Research Scientist - Metabolism and Drug-Drug Interactions

Highly Competitive
  1. Permanent
  2. Clinical Scientist
  3. Switzerland
Lausanne, Switzerland
Posting date: 10 Dec 2020

An excellent opportunity has arisen for a Research Scientist who works in the fields of Metabolism and Drug-Drug Interactions in Switzerland. Scientist with expertise in metabolism analyses to support the discovery and optimisation of small molecules from hit-to-lead to candidate selection. Main focus will be on the supervision of metabolic stability and CYP inhibition studies, reactive metabolite trapping assays, drug-drug interaction (DDI) and transporter studies, CYP induction studies, metabolic profiling and other related assessments.

Job Responsibilities

  • Design, supervise and interpret metabolism investigating studies including those for e.g., reactive metabolite trapping, metabolic stability, CYP inhibition and induction, metabolite identification and profiling
  • Act as primary contact for CROs for the management of outsourced metabolism studies. Support selection of new potential CROs for these studies
  • Perform the metabolite profiling analysis to support the selection of preclinical species for toxicology studies and analyze in vivo circulating metabolites in toxicology and clinical studies
  • Conduct profiling of selected candidates in DDI and transporter studies
  • Perform predictions of metabolic transformations and other metabolism-related properties is a plus
  • Summarize key data in reports, presentations and relevant sections of regulatory documents
  • Complete in a timely manner activities that allow a project to achieve deliverables and milestones
  • Provide drug metabolism expertise as a project team member

Skills and Requirements

  • Ph.D degree in Drug Metabolism, Chemistry, Clinical Pharmacology or a related life science degree. Alternatively, at least 5 years of experience in preclinical development of small molecules, preferably in industry
  • Experience in designing, analyzing and interpreting metabolism studies from hit-to-lead to candidate selection with a track record of understanding the principals, theories and analysis of metabolism, drug disposition and drug interactions
  • Understanding of LC/MS and other analytical methods used for small molecules a plus
  • Demonstrated ability to synthesize, analyze and communicate key information
  • Strong interpersonal skills for building networks with key experts and ensuring the interface with internal departments and external collaborators
  • Ability to adapt priorities to meet company needs while maintaining effectiveness
  • Leadership and project management skills
  • Excellent spoken and written English are required

To Apply

ProClinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.