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Job type: Permanent

Discipline: Biochemistry, Biological Sciences, Molecular Biology

Location: United States

Proclinical is seeking an Associate Director/Principal Scientist to join a new biotechnology company developing oligonucleotide therapeutics for genetic diseases. We have established a proprietary target discovery engine leveraging large-scale human genetics studies to uncover novel targets where there is significant unmet need. Our lead asset is for the treatment of a severe neurological disease with the potential to be the first disease-modifying therapy in this indication.

Job Responsibilities:

Development, optimization, and troubleshooting of methods to screen and characterize activity of antisense oligonucleotides (ASOs)
Research and development of in vitro assays to evaluate impact of antisense oligonucleotides on RNA transcripts, protein expression, and other project-specific assays
Apply molecular and cell-based assays including but not limited to RNA transfection, RNA & protein isolation, gene expression analysis (RT-qPCR & RNASeq), western blot, and fluorescence immunocytochemistry

Skills and Requirements

Ph.D. degree in molecular biology, RNA biology, biochemistry, neuroscience, or related field
Minimum of 3-5 years' experience working in an industry lab setting with antisense oligonucleotides
Strong molecular biology skills including basics such as qRT-PCR, western blot, primer/probe design, cell transfection, etc.
Extensive experience and demonstrated expertise in mammalian cell culture
Strong understanding of genomics and transcriptomics, including gene regulation and splicing mechanisms
Demonstrated ability to reproduce/adapt published protocols, interpret complex experimental results, and troubleshoot technical issues independently
Experience working with next generation sequencing (ex. RNAseq) a plus
Experiencing managing junior team members and leading projects
Exceptional attention to detail with excellent written and verbal communication skills

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 857-362-9542 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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