Senior Scientist, mRNA Project Leader job in Boston, USA

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First Name*

Last Name*

Email*

Phone Number*

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Are you an employer or a jobseeker?*

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Job type: Permanent

Discipline: Biochemistry, Biological Sciences, Molecular Biology

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is working with a gene therapy start-up company, developing treatments for CNS and other areas of high unmet medical need, located in Boston, MA. Our client is in search for a Senior Scientist, mRNA Project Leader that will participate in the early R&D of innovative mRNA therapies for patients with serious diseases. The position requires passion, engagement and a desire to move projects forward.

Job Responsibilities:

Strategic leader of one (or more) mRNA projects in the areas of immuno/oncology, infectious diseases or vaccination program
Integration of company decisions and business considerations into the project
Prioritization of program key objectives, data reviews and milestone deliverables
Adapting the mRNA therapeutic property to the selected disease profile, increasing the chance of successful treatment in patients
Monitoring changing regulatory requirements, as well as competitive landscape
Collaboration within the mRNA group, as well across other functions
As a team effort, identification of animal models for Non-GLP and GLP toxicology studies
Demonstration of efficacy, durability and safety (especially immuno-safety) for innovative mRNA therapeutics and delivery vehicles, leading to identification of lead molecules within timelines
Collect, analyze and document experimental data
Present the final results to team members and line manager
The successful candidate is expected to do hands-on bench work as requested

Skills and Requirements:

MS in biology or related discipline and 7+ years of relevant research experience
Ph.D. in biology or related discipline and 5+ years of relevant research experience
Prior research experience in biotech or pharmaceutical industry is required, in particular the therapeutic application of mRNA or CRISPR/CAS technologies towards IND filing
Proven track record of leading mRNA programs through IND-enabling studies into clinical development
Sound experience with mRNA therapeutics and in vivo delivery concepts (such as lipid nanoparticles)
Ability to move projects forward and produce data on time
Proficiency in the relevant areas of natural and synthetic mRNA biology (DNA, mRNA, protein)
Understanding how medicinal chemistry efforts enhance mRNA performance
Familiarity with a broad range of bioanalytical, molecular biology methods or biochemical assays to characterize mRNA and its impact on disease progression (such as ELISA, MSD, Flow Cytometry, RT-PCR, Nanostring)
Capacity to identify and solve problems
Excellent oral and written communication skills
Motivation to work independently as part of a very collaborative, international team

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 617-903-7746 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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