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Job type: Permanent

Discipline: Biological Sciences

Location: Switzerland

We are currently in search for a ADME Scientist to join an established pharmaceutical organisation in Switzerland. You will be expected to be contracted for 1 year working on vitro assay techniques to estimate fractions.

Job Responsibilities

Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
Analysing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation.
Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.
Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.

Skills and Requirements

PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
Min 3/5 years of experience in similar position
Experience in bioanalysis & in vitro assays
Experience in industry
Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.
You have a strong interest in translational approaches leveraging in vitro data and clinical data.
Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)

To Apply

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