ADME Scientist

Highly Competitive
  1. Permanent
  2. Biological Sciences
  3. Switzerland
Basel, Switzerland
Posting date: 05 Mar 2021

We are currently in search for a ADME Scientist to join an established pharmaceutical organisation in Switzerland. You will be expected to be contracted for 1 year working on vitro assay techniques to estimate fractions.

Job Responsibilities

  • Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
  • Analysing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation.
  • Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.
  • Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
  • Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.

Skills and Requirements

  • PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
  • Min 3/5 years of experience in similar position
  • Experience in bioanalysis & in vitro assays
  • Experience in industry
  • Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.
  • You have a strong interest in translational approaches leveraging in vitro data and clinical data.
  • Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)

To Apply

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.