Senior Scientist, RNA Biology

Proclinical is seeking a Senior Scientist, RNA Biology for a cutting-edge biotech company located in South San Francisco, CA.

As an RNA Biology Scientist/Senior Scientist, you will guide novel target discovery by assessing the functional role of RNA cis-regulatory elements in cell models of human diseases.

Must be eligible to work in the US.

Job Responsibilities:

• Assess the functional role of RNA cis-regulatory elements in RNA processing, splicing, translation, or stability using cellular and genetic methods. Assemble top-quality data packages on novel RNA targets.
• Onboard, validate, and maintain cell models of human diseases.
• Onboard and develop assays to validate the function of RNA-modulating small molecules in cell disease models.
• Direct and mentor research associates.
• Analyze, interpret, and organize data, and clearly document and communicate research outcomes to colleagues.
• Work within a collaborative, high-caliber, interdisciplinary team.

Skills and Requirements:

• Ph.D. in Biology, Genetics, Biochemistry, Molecular Biology, or related field.
• 3+ years of industry experience in relevant biotech or pharma environments.
• Deep understanding of mammalian RNA regulation mechanisms.
• Extensive experience with a variety of methods for transient and stable genetic manipulation of cells, such as transfection, ASOs, siRNA, CRISPR editing, lentivirus, or baculovirus.
• Experience with the design, construction, and readout of reporter or minigene assays.
• Experience with rigorous quantitation of RNA and protein abundance in cells, such as RT-qPCR, ddPCR, ELISA, or AlphaLISA.
• Experience using and developing cell models of disease. Excellent cell culture skills for a variety of mammalian cell types, including iPSCs and primary cells.
• Adept in applying these methods to test and develop scientific hypotheses. Mature in scientific thinking and rigorous in recording methodologies and results.
• Familiar with concepts and methods in small molecule drug discovery.
• Excellent presentation and writing skills, able to clearly communicate technical information to colleagues.
• Familiar with genomic methods for assessing RNA function, such as RNA-seq, scRNA-seq, ribosome footprinting, eCLIP, etc.
• Familiar with experimental and computational methods used to measure, model, and analyze RNA secondary or 3D structure.
• Proficient in data analysis using Python (or similar language) and common bioinformatics tools.

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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