(Senior) Scientist, Nucleic Acid Process Development

Proclinical is currently recruiting for a Senior Scientist Nucleic Acid Process Development for a leading biotechnology company located in Cambridge, MA. As the Nucleic Acid Process Development Sr. Scientist, you will provide technical/scientific expertise and leadership in all areas of drug process development such as loading, cleanup, filtration, and formulation.

Job Responsibilities:

• Design, execute, and analyze pioneering loading processes for diverse molecules, including ASOs, siRNA, mRNA, and small molecules.
• Develop unit operations to enable cleanup and formulation of durably loaded drug product.
• Scale-up processes from bench to pilot and cGMP clinical manufacturing scale, including technology transfer through clinical manufacturing.
• Create state-of-the-art small-scale models and characterization capabilities.
• Identify, engage, and manage external collaborators to explore new loading technologies
• Assist in the development and execution of purification processes as needed.
• Seek to connect structural attributes and functional potency of loaded drug product.
• Perform document writing, data interpretation, presentation, statistical analysis, and trending.
• Serve as function lead on pipeline programs to guide them to successful completion, requiring cross-functional collaboration and scientific and technical expertise.
• Author scientific manuscripts and patents. Present work internally and externally.
• Aid in the authoring of Regulatory documents.

Skills and Requirements:

• PhD in chemistry, polymer chemistry, biochemical engineering or similar disciplines with a minimum of 2 years related experience; expert knowledge of scientific principles and concepts.
• Proficient in organic, polymer, and bioconjugation chemistry.
• Experience developing processes with exosomes, liposomes, and/or lipid nanoparticles.
• Background in applying advanced technologies to develop methods for loading of payloads into and onto nanoparticles.
• Experience in development and transfer of production processes for nanoparticles to cGMP manufacturing organizations.
• Demonstrated technical proficiency, work ethic, scientific creativity, collaboration with others and independent thought.
• Excellent communication and presentation skills (oral and written).
• Reputation as emerging leader in field with sustained performance and accomplishment.

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 617-903-7746 or m.robinson@proclinical.com

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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