Senior Scientist, mRNA Cancer Vaccines job in Boston, USA

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

First Name*

Last Name*

Email*

Phone Number*

Country*

Are you an employer or a jobseeker?*

Message

Job type: Permanent

Discipline: Senior/Director & VP, Analytical Chemistry, Biochemistry

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is currently recruiting for a Senior Scientist of mRNA Cancer Vaccines for a global pharmaceutical company located in Boston, MA. As the Senior Scientist, you will work in the state-of-the-art laboratory and be responsible for experimental development, execution and data analysis for preclinical research studies supporting cutting edge therapeutic mRNA vaccine research and precision immuno-oncology therapeutic development.

Job Responsibilities:

Develop and execute experimental bench work to build up neoantigen vaccine and therapeutic mRNA platform
Design and execute neoantigen peptide identification and production
Design and optimize DNA constructs for in vitro mRNA production, candidate screening and lead selection
Design and conduct in vitro and in vivo pharmacology, safety and efficacy studies
Collaborate with internal and external collaborators
Performing data analyses and delivering data presentation to the scientific team
Ensuring maintenance of industry-quality records to provide documentation
Contribute to high impact research publications/patent applications and regulatory filings

Skills and Requirements:

PhD + several years experience in mRNA chemistry/biology; nanomedicine; nucleic acid pharmacology; synthetic nucleic-acid-based vaccines, immunotherapy, oncology or related discipline
Deep knowledge in mRNA biology and clinical applications of mRNA therapy
Deep knowledge in tumor biology, immunotherapy, and neoantigen vaccinology
Hands-on experience in neo-antigen identification and production
Hands-on experience with various molecular biology techniques, including DNA/RNA operations, in vitro transcription for mRNA synthesis, quantitative PCR, RT-qPCR, branched DNA assay, ddPCR, expression vector design, NGS, shRNA and miRNA
Hands-on experience in mammalian cell cultures, cell-based assays and immunological assays for drug research and development
Familiar with and willing to work with rodent tumor models
Outstanding problem-solving and troubleshooting skills
Must be self-motivated, detail-oriented, organized
Must be capable of working independently as well as in a collaborative/group environment
Good communication and interpersonal skills
Ability to multi-task in a fast-paced work environment
Strong commitment to accountability with can-do attitude for completion of projects in accordance with team plans and timelines

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 617-903-7746 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

#LI-MR3