Senior Scientist, mRNA Cancer Vaccines

Proclinical is currently recruiting for a Senior Scientist of mRNA Cancer Vaccines for a global pharmaceutical company located in Boston, MA. As the Senior Scientist, you will work in the state-of-the-art laboratory and be responsible for experimental development, execution and data analysis for preclinical research studies supporting cutting edge therapeutic mRNA vaccine research and precision immuno-oncology therapeutic development.

Job Responsibilities:

• Develop and execute experimental bench work to build up neoantigen vaccine and therapeutic mRNA platform
• Design and execute neoantigen peptide identification and production
• Design and optimize DNA constructs for in vitro mRNA production, candidate screening and lead selection
• Design and conduct in vitro and in vivo pharmacology, safety and efficacy studies
• Collaborate with internal and external collaborators
• Performing data analyses and delivering data presentation to the scientific team
• Ensuring maintenance of industry-quality records to provide documentation
• Contribute to high impact research publications/patent applications and regulatory filings

Skills and Requirements:

• PhD + several years experience in mRNA chemistry/biology; nanomedicine; nucleic acid pharmacology; synthetic nucleic-acid-based vaccines, immunotherapy, oncology or related discipline
• Deep knowledge in mRNA biology and clinical applications of mRNA therapy
• Deep knowledge in tumor biology, immunotherapy, and neoantigen vaccinology
• Hands-on experience in neo-antigen identification and production
• Hands-on experience with various molecular biology techniques, including DNA/RNA operations, in vitro transcription for mRNA synthesis, quantitative PCR, RT-qPCR, branched DNA assay, ddPCR, expression vector design, NGS, shRNA and miRNA
• Hands-on experience in mammalian cell cultures, cell-based assays and immunological assays for drug research and development
• Familiar with and willing to work with rodent tumor models
• Outstanding problem-solving and troubleshooting skills
• Must be self-motivated, detail-oriented, organized
• Must be capable of working independently as well as in a collaborative/group environment
• Good communication and interpersonal skills
• Ability to multi-task in a fast-paced work environment
• Strong commitment to accountability with can-do attitude for completion of projects in accordance with team plans and timelines

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 617-903-7746 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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