Senior Scientist, Computational Biology

Proclinical is seeking a highly motivated Senior Scientist to join the Computational Biology group of a disruptive Cancer Immunotherapy Biotech in Cambridge MA. As the Senior Scientist, you will integrate clinical and research datasets, including mass spectrometry and next-generation sequencing data. The successful candidate will develop novel methods, analysis strategies, and tools to filter and distill multi-dimensional datasets into focused hypotheses that drive clinical and discovery research.

Job Responsibilities:

• Identify novel immuno-oncology targets by utilizing integrative approaches to multi-modal omics datasets
• Drive antigen discovery to feed vaccine and cellular therapies pipelines (including CAR, TCR, and ex vivo induced T cells).
• Conduct correlative analysis of patient outcomes, phenotypes, and immune readouts with diverse high dimensional data types to identify biomarkers and mechanistic hypotheses about response and resistance to novel immunotherapies.
• Contribute to the development and benchmarking of new neoantigen prediction algorithms
• Develop innovative, robust, analysis pipelines that can be applied in research and clinical settings
• Liaise with experts in immunology, clinical medicine, infectious disease, machine learning experts, and software engineering as a project team member and provide expertise as a scientific resource for key company programs
• Identify, develop, manage, and contribute to collaborations and partnerships
• Provide guidance on experimental design and data interpretation by engaging lab scientists
• Serve as a project team member and a scientific resource for key company programs

Skills and Requirements:

• Ph.D. in bioinformatics, computational biology, systems biology, or a related discipline with a strong record of publications/patents is required.
• Experience developing and optimizing NGS-based software for cancer and/or immunology research (e.g., variant calling, gene expression, epigenetic analyses, single-cell sequencing approaches).
• Fluency in SAM/BAM file format specifications and other standard bioinformatic formats.
• Proficiency with the following:
• Experience integrating diverse NGS and non-NGS data sets to identify cancer drivers, predictive biomarkers, or mechanistic hypotheses
• Experience with mining public data sets, such as TCGA, GTEx, and CCLE
• Demonstrated ability to formulate and test hypotheses by designing and implementing novel computational approaches
• Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
• Ability to work effectively with collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
• Strong written and verbal skills; ability to translate and communicate complex information and concepts for scientists of diverse backgrounds
• Positive and collaborative attitude; ability to work effectively with internal and external collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
• Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
• Creative and innovative thinking; track record of thought leadership

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 857-362-9542 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

#LI-MR3