Screening and Assay Development Lead

Proclinical is seeking a Screening and Assay Development Lead for a cutting-edge biotechnology company located in South San Francisco, CA.

As the Screening and Assay Development Lead, you will spearhead efforts to develop, optimize, establish, and execute biochemical/molecular assays for screening small molecule modulators of RNA targets.

Must be eligible to work in the US.

Job Responsibilities:

• Develop, qualify, and validate novel and standard assays in-house. Ensure reproducibility and consistency of screening results and methods.
• Provide scientific leadership and in-depth knowledge for biochemical, molecular, and cell-based assays, and interpretation of results.
• Independently, proactively, and effectively troubleshoot assay-related issues.
• Hire and mentor new members of the team.

Skills and Requirements:

• Bachelor's degree and a minimum of 15 years of experience in the industry or PhD in the life sciences and minimum of 10 years of experience in the industry.
• Extensive experience in developing and establishing novel and off-the-shelf biochemical, molecular, and cellular assays (cell lines, primary cells, viability/cytotoxicity, ELISA, Western, qPCR, MSD, microscopy, flow cytometry, etc.).
• Proficiency in designing, cloning, and working with plasmid- or mRNA-based reporter systems
• Hands-on familiarity with small molecule library screening, including lab automation for medium- and high-throughput formats (96- and 384-well plates).
• Demonstrated experience with multiple nucleic acid delivery system platforms (electroporation, transfection, viral and non-viral delivery systems).
• Substantial experience in managing and mentoring teams.
• Ability to plan and execute in a fast-paced environment and agility to adapt to changing priorities.
• Excellent presentation and writing skills, ability to clearly communicate technical information to colleagues.
• Experience screening small molecule modulators of RNA targets.
• Deep understanding of mechanisms and pathways regulating mRNA processing in mammalian cells.
• Experience managing and working with CROs to increase screening throughput and deliver results efficiently and cost-effectively.

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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