Scientist, mRNA Process Development job in Woburn, USA

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Job type: Permanent

Discipline: Bioprocessing, Genetics & Genomics, Molecular Biology

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is urgently recruiting for a Scientist of mRNA Process Development for a leading life science research and development group located in Woburn, MA. As the Process Development Scientist, you will work to develop first-in-class messenger RNA (mRNA) based therapeutics and vaccines.

Job Responsibilities:

Apply deep knowledge in nucleic acid research to lead mRNA process platform development
Lead screening, optimization, and scale-up efforts on enzymatic reaction and IVT synthesis including plasmid digestion, mRNA synthesis, nucleobase modifications and post-transcriptional modifications.
Design and execute DOE studies & high-throughput screen for process improvements and advancements
Support the development of automated mRNA production process to supply high-quality mRNA for lead candidate screen
Support the development of robust physicochemical, chromatographic, and molecular and cell-based assays for in-process controls and final product release testing.
Work closely with cross-functional teams including CMC scientists to develop mRNA production strategies to meet ambitious project timeline.
Communicate effectively with regular verbal and formal updates to project teams and management.
Maintain necessary documents including laboratory notebooks, process development reports, technical transfer records, and process related documents.
Build and promote the company's value and culture, result oriented, work with can-do attitude, team player mentality, constantly inject positive energy into the working environment.

Skills and Requirements:

Degree in Molecular Biology, Genetics, Biotechnology, Bioengineering, or a related scientific field. BS with 10+ years of directly related experience, MS with 8+ years of directly related experience, or PhD with 4+ years (preferred) of directly related experience.
Strong understanding of nucleic acid chemistry, enzymatic and chemical reactions, and mRNA process at bench and larger scales.
Strong hands-on skills in nucleic acid handling and manipulation including plasmid preparation, in vitro transcription, purification, and cleanup is a must.
Proficient in analytical technologies including HPLC, agarose gel electrophoresis, capillary electrophoresis, qPCR, ELISA is required.
Experience in high-throughput screen and DOE statistical tools for process development techniques is desired.
Experience with automated systems and programming is a strong plus
Experience in author & technical review on supporting documentations for CMC and regulatory filings is a strong plus.
Experience in cGMP requirements for early phase development is a plus.
An ability to work independently, meet deadlines and prioritize work effectively. Must be able to thrive and deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment.
Demonstrated capabilities to implement advance technologies and persist to successful outcomes.
Experience in large-scale process of mRNA automation synthesis and purification is highly desired.

If you are having difficulty in applying or if you have any questions, please contact Phil Sawyer at (+1) 617-545-5923 or p.sawyer@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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