Principal Scientist, Translational Bioinformatics

Proclinical is currently recruiting for a Principal Scientist of Translational Bioinformatics with a global biotechnology company located in Princeton, NJ. As a Principal Scientist in Translational Medicine Data Science, you will work with a multidisciplinary, international team of world-class scientists and research associates with state-of-the-art knowledge of the antibody and oncology field. The incumbent's task will be to transform oncology by discovering and developing antibody therapeutics that serve cancer patients with unmet medical needs.

Job Responsibilities:

• Play a pivotal role in the development and expansion of cutting-edge bioinformatics and computational tools and capabilities within the team.
• Utilize computational tools and approaches to partner with the Translational Medicine laboratory to analyze flow cytometry, gene expression, and a multitude of immune profiling assays to increase conviction in the mechanism(s) of action and predict safety and liability features of drug candidates.
• Use external low, medium, and high-density data to complement and provide added context to internally produced data.
• Design, expand, and maintain internal pipelines for relevant computational analyses.
• Work seamlessly with colleagues from Discovery Research and Clinical Development to bridge and integrate relevant data that informs conviction in assets (Mechanisms of action, liabilities, biomarker plans, patient stratification, etc…).
• Socialize and establish intuitive data analysis and visualization tools with biologists/immunologists and translational scientists.
• Manage bioinformatics projects, both in-house as well as outsourced to service providers.
• Continue to stay up to date on the latest relevant scientific literature and translate your learnings into evolving best practices.
• Report scientific results in patents, publications, regulatory documents, and product-development reports.

Skills and Requirements:

• Must have PhD (highly preferred) or MS degree in immunology, biology, with bioinformatics, computational biology background, or vice versa.
• Knowledge and a good understanding of bioinformatics, mainly as applied to translational research, preferably in the oncology setting.
• Excellent programming skills (Java, Python, R, etc…) and experience in using relational databases like Oracle, MySQL or PostgreSQL as well as cloud services for storage and computing (AWS-S3, etc…)
• In-depth knowledge and practical experiences with high-density data types and relevant external resources (genomics, transcriptomics, proteomics, flow cytometry, TCR sequencing, immune assays, etc…)
• Ability to implement/adopt new algorithms for data analysis
• Experience with regulated environments such as ISO/GCP/GMP when working with tools and databases.
• Published in high-quality journals, references, and external presentations.
• You have a 'getting things done' mentality; you are creative, pro-active, enthusiastic, out-of-the-box thinking, and goal orientated.
• Significant experience managing a team of computational biologists or bioinformatics to deliver results.
• design fit for purpose experiments that enable decision making and lend themselves to scalability.
• Demonstrated ability to collaborate with a diverse and global group of scientists, research associates.

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 929-388-1651.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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