Principal Scientist to Director, Capsid Engineering

Proclinical is seeking a Principal Scientist to Director, Capsid Engineering for a cutting-edge biotech company located in Boston, MA.

In this role, you will be responsible for establishing and leading a AAV capsid discovery and engineering team to support AAV drug development.

Must be eligible to work in the US.

Job Responsibilities:

• Establish, manage, and lead the capsid discovery and engineering platform
• Design, develop and implement the production of AAV capsid libraries
• Characterize and validate novel AAV capsid libraries
• Establish approaches to identify novel AAV capsid variants that transduce specific cell types in both rodents and NHPs
• Utilize NGS and machine learning to further enhance development of novel AAV with tailored properties
• Supervise and conduct viral vector design, molecular cloning, plasmid prep, sequencing, viral vector production, and QC
• Communicate and manage external CRO to support research activities
• Oversee and report the progress of projects timely, stay on timelines
• Maintain detailed and well-organized documentation with best industry practice
• Train, mentor, and supervise scientists
• Support IND filing

Skills and Requirements:

• A Ph.D. in molecular biology, cell biology, structural biology, virology, immunology, or related discipline is required
• Expertise in the design and construction of AAV libraries is required
• 4+ years of direct capsid discovery and engineering experience is required
• Familiar with the whole process of AAV capsid discovery
• Good knowledge in NGS and bioinformatics
• Extensive knowledge of AAV biology
• Extensive and excellent hands-on skills and experience with cell and molecular biology techniques, and assay development are required
• Extensive experience with animal tissue handling and bioanalytical assays
• Experience in developing procedures for the extraction of high quality of RNA and DNA from various mammalian tissues and scaling these procedures to high throughput workflows
• Experience in generation and/or computational analysis of high-throughput data
• Outstanding critical thinking and problem-solving skills
• Responsible and efficient with work assignments
• Can do attitude and quick and high-quality execution
• Exceptional ability in team management
• Ability to work under pressure and meet tight deadlines
• Ability to be highly productive in a fluid, fast-paced team environment
• Excellent oral and written communication skills

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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