Principal Scientist to Director, Capsid Engineering job in Boston, USA

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Job type: Permanent

Discipline: Senior/Director & VP, Biological Sciences, Pharmacology

Location: United States

This vacancy has now expired. Please see similar roles below...

Proclinical is seeking a Principal Scientist to Director, Capsid Engineering for a cutting-edge biotech company located in Boston, MA.

In this role, you will be responsible for establishing and leading a AAV capsid discovery and engineering team to support AAV drug development.

Must be eligible to work in the US.

Job Responsibilities:

Establish, manage, and lead the capsid discovery and engineering platform
Design, develop and implement the production of AAV capsid libraries
Characterize and validate novel AAV capsid libraries
Establish approaches to identify novel AAV capsid variants that transduce specific cell types in both rodents and NHPs
Utilize NGS and machine learning to further enhance development of novel AAV with tailored properties
Supervise and conduct viral vector design, molecular cloning, plasmid prep, sequencing, viral vector production, and QC
Communicate and manage external CRO to support research activities
Oversee and report the progress of projects timely, stay on timelines
Maintain detailed and well-organized documentation with best industry practice
Train, mentor, and supervise scientists
Support IND filing

Skills and Requirements:

A Ph.D. in molecular biology, cell biology, structural biology, virology, immunology, or related discipline is required
Expertise in the design and construction of AAV libraries is required
4+ years of direct capsid discovery and engineering experience is required
Familiar with the whole process of AAV capsid discovery
Good knowledge in NGS and bioinformatics
Extensive knowledge of AAV biology
Extensive and excellent hands-on skills and experience with cell and molecular biology techniques, and assay development are required
Extensive experience with animal tissue handling and bioanalytical assays
Experience in developing procedures for the extraction of high quality of RNA and DNA from various mammalian tissues and scaling these procedures to high throughput workflows
Experience in generation and/or computational analysis of high-throughput data
Outstanding critical thinking and problem-solving skills
Responsible and efficient with work assignments
Can do attitude and quick and high-quality execution
Exceptional ability in team management
Ability to work under pressure and meet tight deadlines
Ability to be highly productive in a fluid, fast-paced team environment
Excellent oral and written communication skills

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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INDSCIC

Salary

Highly Competitive Salary

Location:

Wrexham, Wales

Proclinical is seeking a Senior Principal Scientist to lead strategic projects in biomanufacturing processes, focusing on API/Drug substance processing.