Principal Scientist to Director, Capsid Engineering

Highly Competitive Salary
  1. Permanent
  2. Senior/Director & VP, Biological Sciences, Pharmacology
  3. United States
Boston, USA
Posting date: 03 Oct 2023

This vacancy has now expired. Please see similar roles below...

Proclinical is seeking a Principal Scientist to Director, Capsid Engineering for a cutting-edge biotech company located in Boston, MA.

In this role, you will be responsible for establishing and leading a AAV capsid discovery and engineering team to support AAV drug development.

Must be eligible to work in the US.

Job Responsibilities:

  • Establish, manage, and lead the capsid discovery and engineering platform
  • Design, develop and implement the production of AAV capsid libraries
  • Characterize and validate novel AAV capsid libraries
  • Establish approaches to identify novel AAV capsid variants that transduce specific cell types in both rodents and NHPs
  • Utilize NGS and machine learning to further enhance development of novel AAV with tailored properties
  • Supervise and conduct viral vector design, molecular cloning, plasmid prep, sequencing, viral vector production, and QC
  • Communicate and manage external CRO to support research activities
  • Oversee and report the progress of projects timely, stay on timelines
  • Maintain detailed and well-organized documentation with best industry practice
  • Train, mentor, and supervise scientists
  • Support IND filing

Skills and Requirements:

  • A Ph.D. in molecular biology, cell biology, structural biology, virology, immunology, or related discipline is required
  • Expertise in the design and construction of AAV libraries is required
  • 4+ years of direct capsid discovery and engineering experience is required
  • Familiar with the whole process of AAV capsid discovery
  • Good knowledge in NGS and bioinformatics
  • Extensive knowledge of AAV biology
  • Extensive and excellent hands-on skills and experience with cell and molecular biology techniques, and assay development are required
  • Extensive experience with animal tissue handling and bioanalytical assays
  • Experience in developing procedures for the extraction of high quality of RNA and DNA from various mammalian tissues and scaling these procedures to high throughput workflows
  • Experience in generation and/or computational analysis of high-throughput data
  • Outstanding critical thinking and problem-solving skills
  • Responsible and efficient with work assignments
  • Can do attitude and quick and high-quality execution
  • Exceptional ability in team management
  • Ability to work under pressure and meet tight deadlines
  • Ability to be highly productive in a fluid, fast-paced team environment
  • Excellent oral and written communication skills

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.