Genomics Senior Research Associate - Contract - San Deigo, CA
Ready to be the heartbeat of medical research? Join our client as a Research Associate and assist in turning innovative science into life-changing care!
Proclinical is seeking a Research Associate to support the development and optimization of genomics workflows.
Primary Responsibilities:
This role involves integrating novel genomics pipelines into broader operational networks, standardizing processes, and driving efficiency in research and development efforts. You will work largely independently to optimize nuclei extraction protocols across diverse biological variables and execute sophisticated multi-omics workflows.
Skills & Requirements:
- Academic background in molecular biology, biochemistry, genetics, biotechnology, or a related field.
- 4+ years of relevant experience, demonstrating a strong track record of independent troubleshooting in a molecular biology/genomics context.
- Hands-on experience with single-cell or single-nuclei sequencing workflows (e.g., 10x Genomics Multiome).
- Practical experience with nuclei isolation and extraction from frozen tissues
- Ability to work independently, design optimization experiments, and interpret quality control data (e.g., Bioanalyzer/TapeStation traces) without oversight.
- High level of computer literacy to maintain detailed electronic lab notebooks (ELN) and sample records.
- Highly organized and self-motivated, able to manage complex workflows involving sensitive reagents and strict timelines.
- Meticulous attention to detail with a solution-driven mindset, particularly regarding protocol troubleshooting
The Genomics Senior Research Associate's responsibilities will be:
- Lead optimization efforts for nuclei extraction across a complex matrix of tissue types, including multi-species, disease-state, and variable-age samples
- Independently execute and troubleshoot advanced genomic protocols, including novel genomics protocols, Multiome, and MINT-ChIP
- Be responsible for the end-to-end processing of samples, from frozen tissue handling to library preparation, ensuring high-quality inputs for sequencing
- Systematically track optimization metrics to establish robust standard operating procedures (SOPs) for challenging tissue types.
- Lead efforts to implement and maintain inventory and sample tracking systems for high-value genomic libraries.
- Work closely with computational and wet-lab colleagues to plan large-scale data collection and ensure experimental designs meet analytical requirements.
- Set up and operate laboratory equipment (e.g., cell counters, thermocyclers, microfluidics platforms), prepare reagents, record and consolidate research data, and execute planned research activities with minimal supervision
If you are having difficulty applying or if you have any questions, please contact Shannon Briggs at s.briggs@proclinical.com
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
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