Executive Director Medicinal Chemistry - Home-Based

Proclinical are recruiting an Executive Director Medicinal Chemistry for a biotech organisation. This role is on a permanent basis with the ability to work remotely from anywhere within the UK.

Responsibilities:

• Accountable for the distribution of lead and candidate milestones.
• Guide various drug discovery programmes as the scientific lead, outlining and owning the target product profile (TPP).
• Form solid relationships with the technology team as well as assume ownership of the company's vision to revolutionise drug discovery through the use of modern AI and ML approaches.
• Collaborate with the VP, medicinal chemistry to consistently look for ways to improve the efficiency and methods facilitating project and portfolio delivery.
• Offer guidance, cooperate with computational designers to set general methodical medicinal chemistry goals.
• Other duties may be assigned to this role.

Key Skills and Requirements:

• Educated to an advanced degree level with at least 12+ years of experience working at a pharma or biotech organisation in an influential medicinal chemist role.
• Familiarity with guiding multidisciplinary small molecule drug discovery programs from hit selection through to candidate selection and profiling.
• A motivated individual with the ability to make decisions.
• Expertise on modern facets of small molecule optimisation which involves quality metrics, computer-aided drug design, the role of physiochemical properties in compound quality, comprehension of in vitro and in vivo PK studies and the key aspects that drive human dose.
• Capable of embracing and promoting all facets of modern drug discovery technologies.
• Able to implement and advocate algorithm-derived compound designs and the company's drug discovery philosophy.
• Communication skills both verbally and in writing.
• Acquaintance with data analysis workflows and using data analysis tools such as Spotfire.
• Prior involvement in implementing data modelling approaches such as regression and/or classification methods.
• Work well with others as well as independently.
• Know-how in ADMET, computational chemistry or structural biology applications to contemporary drug discovery.
• Experience with late pre-clinical teams.
• Expertise on the process leading to a phase I reast asset as well as of QSPR approaches to exploit predictions of ADME properties.
• Acquaintance with various target classes such as GPCRs, proteases, NHR, kinases.

If you are having difficulty in applying or if you have any questions, please contact Dominic Williams at +44 203 987 6281.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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