Associate Principal Scientist, Translational PKPD Modeling

Highly Competitive Salary
  1. Permanent
  2. Senior/Director & VP, Pharmacokineticists, Pharmacology
  3. United States
Waltham, USA
Posting date: 16 Feb 2021
SC.NP.35721

Our client, a global biopharmaceutical company focusing on the research, development, and manufacturing of pharmaceutical products is searching for an Associate Principal Scientist of Translational PKPD Modelling and DMPK. As the Associate Principal Scientist, you will have the opportunity to drive strategy in PKPD science across our diverse portfolio. Your day-to-day role is to provide projects with expert modelling input into exploring the PK/PD/Efficacy in pre-clinical models and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Job Responsibilities:

  • Representing Oncology DMPK and providing overall scientific leadership for cross functional and external collaborations involving DMPK.
  • Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).
  • Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.
  • Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.
  • Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.
  • Having a breadth of influence and impact across DMPK and externally within their discipline.
  • Identifying, championing and developing new ideas.
  • Leading scientific discipline networks and acting as a focus for debate within the scientific community.
  • Advising on and participating in the development of Discovery or Development strategies in PKPD for biologics/ADCs/small molecules.
  • Managing student and Post Doc programmes.
  • Leading external collaborative projects with academic or cross-pharma pre-competitive groups.
  • Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Skills and Requirements:

  • PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences or applied mathematics.
  • PhD with at least 3+ years of relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting, or a MS degree with at least 7+ years of relevant industry experience.
  • Experience in a project-facing role at pharmaceutical R&D.
  • Good understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record.
  • Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost.
  • Experience using tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.

If you are having difficulty in applying or if you have any questions, please contact Natasha Patel at (+1) 617-778-7319 or n.patel@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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