Associate Director, Translational PKPD Modeling & DMPK job in Waltham, USA

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Last Name*

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First Name*

Last Name*

Email*

Phone Number*

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Are you an employer or a jobseeker?*

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First Name*

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Job type: Permanent

Discipline: Senior/Director & VP, Pharmacokineticists, Pharmacology

Location: United States

This vacancy has now expired. Please see similar roles below...

Our client, a global biopharmaceutical company focusing on the research, development, and manufacturing of pharmaceutical products is searching for an Associate Director of Translational PKPD Modelling and DMPK. As a senior Translational PKPD Modeling and Simulation scientist, you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio. Your day-to-day role is to provide projects with expert modeling input into exploring the PK/PD/Efficacy in pre-clinical models and using these models to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Job Responsibilities:

Representing Oncology DMPK and providing overall scientific leadership for cross functional and external collaborations involving DMPK.
Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).
Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.
Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.
Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.
Having a breadth of influence and impact across DMPK and externally within their discipline.
Identifying, championing and developing new ideas.
Leading scientific discipline networks and acting as a focus for debate within the scientific community.
Advising on and participating in the development of Discovery or Development strategies in PKPD for biologics/ADCs/small molecules.
Managing student and Post Doc programmes.
Leading external collaborative projects with academic or cross-pharma pre-competitive groups.
Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Skills and Requirements:

PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences or applied mathematics.
At least 7+ years of relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting, or a MS degree with at least 10+ years of relevant industry experience.
Experience in a project-facing role at pharmaceutical R&D.
Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record.
Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost.
Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
Excellent interpersonal and communication skills.
Strong influence and leadership skills.
Experience in providing modeling support for other modalities in addition to small molecules is a plus.

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at (+1) 617-903-7746 or m.robinson@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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