Upstream Development Associate

A leading pharmaceutical recruitment company known for their work in biotherapeutics is advertising a vacancy for an Upstream Development Scientist. The organisation harnesses and energises the natural trafficking capabilities of extracellular vesicles to develop an entirely new biotherapeutic class. By utilising ground-breaking exosome technology, the company aims to revolutionise the treatment of a broad range of severe diseases with profound implications for human health.

The Development Associate will assist in material manufacturing using shake flasks and wave bag bioreactors. Moreover, this individual will also be involved in supporting up-stream process development projects. The associate will be required to use their knowledge of theory, techniques and equipment to interpret and perform experimental protocols and studies for the purposes of reporting and analyzing data and developing new or modifying existing processes or assays.

Job Responsibilities:

• Excellent aseptic technique
• Mammalian cell culture (adherent and/or suspension cultures)
• Produce exosome harvests to support internal and external pipeline studies
• Produce exosome material for downstream process development and process characterisation.
• Wave bag and/or stir tank bioreactor use for larger scale runs
• Up-stream process development
• Execute good documentation practices.
• The development associate will be required to plan their daily workload, (e.g. the operation of equipment, cell culture, bioreactor runs, data analysis and report writing) based on experimental plans and timescales set out by their supervisor.
• The development associate will also be required to recognise, record and inform their supervisor of issues pertaining to particular operational problems or scientific/technical issues relating to their daily workload
• Offer suggestions for resolution of technical issues based on experience
• The development will be expected to show creativity in resolving issues.
• The development associate will be required to communicate verbally and in writing within the CMC group.
• Present scientific data at internal CMC meetings.
• Write/revise/review SOP's, risk assessments, protocols and reports.
• Perform laboratory tasks including general housekeeping, equipment monitoring and maintenance.
• Troubleshoot equipment and methods within the process development and manufacturing teams.

Skills and Requirements:

• BSc or MSc in Biological Sciences/cell biology.
• 1-5 years' experience in a relevant work environment.
• Experience with aseptic mammalian cell culture.
• Experience with large scale manufacturing / bioprocessing.
• Experience of operating Bioreactor systems (Stirred tank / hollow fiber / Wave systems).
• Demonstrable multitasking, project management, and execution skills.
• Good interpersonal skills, including communication, presentation, persuasion, and influence.
• Good organisational skills, including efficiency, punctuality, and collaboration in a team environment.
• Proficiency with computer skills, such as MS Office.

To Apply:

Please click on the Apply button. Please include a short note outlining why you are interested in the role and why you think you are suitable.

In case you have difficulty in applying or if you have any questions, please contact Charlotte Allen at +44 203 854 2621 or upload your CV on our website - www.Proclinical.com.

A full job description is available on request.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

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