Scientist

Highly Competitive Salary
  1. Permanent
  2. Biological Sciences, Immunology, Molecular Biology
  3. United States
New York, USA
Posting date: 16 Mar 2021
SC.SA.35854

Proclinical is currently recruiting for a Scientist for a global dynamic drug discovery team located in New York, NY. As the Scientist, you will develop cutting-edge CAR-T therapeutics for the treatment of hematologic malignancies and solid tumors.

Job Responsibilities:

  • Lead in the planning, design and execution of experiments
  • Interpret, troubleshoot and report complex data to managers in a clear and concise manner
  • Demonstrate the ability to manage multiple experiments / projects simultaneously
  • Ability to contribute to various projects outside of his/her own and collaborate with stakeholders
  • Maintain accurate laboratory notebooks and prepare technical reports, summaries, protocols, etc., and maintain familiarity with relevant scientific literature

Skills and Requirements:

  • PhD in biological sciences, immunology, cancer biology or related field with 0-2 years of industry (or postdoctoral) experience or a minimum of 8 years of experience performing progressively advanced duties beyond a B.Sc. degree.
  • Experience in the cancer or immunology fields
  • Ability to independently design, plan and execute in vitro experiments
  • Ability to perform aseptic mammalian tissue culture of cell lines and primary human cells (ie. whole blood, PBMCs, and T cells; BSL2 labs)
  • Experience with T cell engineering (transduction and electroporation) and downstream functional assays
  • Processing and dissociating mouse blood and tumors from in vivo studies for analysis by flow cytometry
  • Perform molecular biology techniques such as: cloning, transfections, transductions, western blotting, immunoprecipitation, siRNA/shRNA, qRT-PCR, flow cytometry and ELISA (ie. MSD)
  • Perform immune functional assays using CAR-T, cytokine release assays, T cell biology, immune cell purification and characterization, tumor dissociation
  • Designing and running multi-color flow cytometry, analysis and interpretation
  • Data analysis using common software programs (ie. Excel, GraphPad Prism, and FlowJo)
  • Keep up-to-date with the literature related to her/his field. Act as an expert resource in her/his scientific and in related disciplines.
  • Candidate must work well in a team setting

Preferred Skills:

  • Previous work with antibody therapies, bispecific antibodies, and cellular therapies (ie. CAR-T)
  • Functional assays to test drug candidates (ie. binding, cytotoxicity, proliferation, apoptosis)
  • Experience working on various immune assays are nice to have
  • Prior experience with isolation, phenotypical and functional characterization of human tumor-infiltrating leukocytes is advantageous
  • Some experience working with in vivo models is a plus (direct handling not required)
  • Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards
  • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
  • Ability to prioritize, manage time efficiently, and implement creative solutions to meet program needs
  • Inclination towards creativity and innovation is welcome

Additional Competencies:

  • Intellectually curious and well-informed on the latest scientific advances in the field
  • Demonstrates creativity and novel approaches to solving scientific problems
  • Strong organizational skills
  • Detail-oriented, with excellent record-keeping skills
  • Able to effectively present scientific data and concepts to international standards
  • Innate ability to find solutions, show initiative

If you are having difficulty in applying or if you have any questions, please contact Sofia Amark at (+1) 646-367-2764 or s.amark@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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